Flucytosine antagonism of azole activity versus Candida glabrata : 3 Role of transcription
نویسندگان
چکیده
9 10 Department of Microbiology and Immunology, Drexel University College of Medicine, 11 Philadelphia, Pennsylvania, 1 and Femeris Women’s Health Research Center, Medical Diagnostic 12 Laboratories, Hamilton, New Jersey 2 13 14 15 Running title: FLUCYTOSINE-AZOLE ANTAGONISM IN CANDIDA GLABRATA 16 17 18 * Corresponding author. Mailing address: Department of Microbiology and Immunology, Drexel 19 University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129. Phone: (215) 991-8337. 20 Fax: (215) 848-2271. E-mail: [email protected] 21 22 AAC Accepts, published online ahead of print on 26 August 2013 Antimicrob. Agents Chemother. doi:10.1128/AAC.02394-12 Copyright © 2013, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Effect of pH on in vitro susceptibility of Candida glabrata and Candida albicans to 11 antifungal agents and implications for clinical use.
The treatment of vulvovaginal candidiasis (VVC) due to Candida glabrata is challenging, with limited therapeutic options. Unexplained disappointing clinical efficacy has been reported with systemic and topical azole antifungal agents in spite of in vitro susceptibility. Given that the vaginal pH of patients with VVC is unchanged at 4 to 4.5, we studied the effect of pH on the in vitro activity ...
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Resistance to 5-flucytosine (5-FC), used as an antifungal drug in combination therapy, compromises its therapeutic action. In this work, the response of the human pathogen Candida glabrata to 5-FC was evaluated at the membrane proteome level, using an iTRAQ-based approach. A total of 32 proteins were found to display significant expression changes in the membrane fraction of cells upon exposure...
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We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C. glabrata FUR1 (CgFUR1) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates.
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OBJECTIVE The purpose of this study was to review the treatment outcome and safety of topical therapy with boric acid and flucytosine in women with Candida glabrata vaginitis. STUDY DESIGN This was a retrospective review of case records of 141 women with positive vaginal cultures of C glabrata at two sites, Wayne State University School of Medicine and Ben Gurion University. RESULTS The bor...
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Patients with vaginitis due to highly azole resistant Candida glabrata can be particularly difficult to treat. We describe three cases of longstanding vaginal candidiasis due to C glabrata. These had failed to respond to local and systemic antifungals. Flucytosine (1 g) and amphotericin B (100 mg) formulated in lubricating jelly base in a total 8 g delivered dose, was used per vagina once daily...
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تاریخ انتشار 2013